Prulax 1 | View Uses, Dosgae, Interaction, Contraindication, Price, Substitutes
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Prulax 1

Generic: Prucalopride

Type: Tablet

Pack Size: 10 Pcs

Prucalopride is prescribed for the treatment of chronic idiopathic constipation in adults. This condition is characterized by:

  • Difficult or incomplete passage of stools.
  • Infrequent stools lasting 3 months or longer.
  • Not caused by any underlying disease or medication.

Not recommended for individuals under 18 due to insufficient safety and effectiveness data.


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Discount Price: ৳ 131.6
MRP: ৳ 140 6% Off

⪼ Save  ৳: 8.4  in this Product


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✅ Description:

Prulax 1 contains Prucalopride, a gastrointestinal prokinetic agent used to treat chronic constipation in adults where conventional treatments (like laxatives) have been ineffective. Constipation is characterized by infrequent, hard, or painful bowel movements.

Prucalopride works by activating specific receptors in the intestinal walls (5-HT4 receptors). This stimulates contractions in the walls of the intestine, increasing the frequency of bowel movements and relieving constipation.

Prulax 1 is contraindicated in:

  • Patients undergoing renal dialysis.
  • Those with perforation or obstruction of the gut wall.
  • Patients with severe inflammation of the intestinal tract, such as Crohn’s disease, ulcerative colitis, or toxic megacolon/megarectum.
  • Patients who have recently undergone bowel surgery.

Use Prulax 1 with caution in patients with:

  • Heart disease.
  • Serious lung disease.
  • Severe kidney or liver disease.

Pregnancy: Not recommended for use. Breastfeeding: Not recommended due to lack of sufficient safety data.

Prulax 1 is not recommended for use in children or adolescents under 18 years of age.

Safety Advices


Alcohol
UNSAFE

It is not known if alcohol interacts with Prulax 1. Please consult your doctor if you have any concerns regarding this.


Pregnancy
UNSAFE

Avoid using Prulax 1 if you are pregnant or breastfeeding.


Breastfeeding
UNSAFE

Not recommended due to lack of sufficient safety data.


Driving

Prulax 1 may cause dizziness and tiredness. Drive only if you feel alert.


Kidney
CAUTION

Prulax 1 is not recommended for use in patients on renal dialysis. It should be used with caution in patients suffering from severe kidney diseases. Consult your doctor for advice before taking it.


Liver
CAUTION

Prulax 1 should be used with caution in patients with severe liver diseases. Consult your doctor before taking it.

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✔️ Uses of Prulax 1
  • Manages chronic constipation in adults
✔️ How does Prulax 1 work?

It acts on the muscle walls of the gut to increase bowel motility, helping to restore normal bowel function and alleviate constipation.

✔️ Side Effects of Prulax 1

You may experience:

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain

Most side effects are mild and resolve over time. However, consult your doctor if any side effects persist or worsen.

✔️ Quick Suggestions:
  • Prucalopride helps treat chronic constipation and improve bowel movements when laxatives have failed to provide adequate relief.
  • It can be taken with or without food, at any time of the day.
  • It may cause diarrhea. Drink plenty of water and inform your doctor if it bothers you.
  • Inform your doctor if your constipation has not improved even after four weeks of taking this medication.
✔️ Indication of Prulax 1

Prucalopride is used in the treatment of constipation. It helps in relieving constipation that is long-lasting or keeps coming back.

✔️ Pharmacology

Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be found throughout the gastrointestinal tract primarily in smooth muscle cells, enterochromaffin cells, and myenteric plexus. Its activation produces the release of acetylcholine which is the major excitatory neurotransmitter in the GI tract. Hence, prucalopride stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract which causes a release of acetylcholine and further contraction of the muscle layer of the colon and relaxation of the circular muscle layer leading to the propulsion of luminal content.

✔️ Dosage & Administration of Prulax 1
  • Take Prucalopride as long as prescribed by your doctor.
  • Note: It's important to follow your doctor's instructions regarding dosage.
  • Renal Impairment:
    • Severe: 1 mg once daily (GFR <30 ml/min/1.73 m²).
    • Mild to Moderate: No dose adjustment required.
  • Hepatic Impairment:
    • Severe: Start with 1 mg once daily, may increase to 2 mg if tolerated.
    • Mild to Moderate: No dose adjustment required.
✔️ Interaction

Keep your doctor informed about your health status and any medications you are taking to avoid potential interactions or unpleasant side effects.

✔️ Contraindications
  • They are contraindicated in individuals who are hypersensitive to prucalopride or any of its excipients.
  • It is not recommended for patients with renal impairment requiring dialysis.
✔️ Pregnancy & Lactation
  • Pregnancy: Not recommended for use during pregnancy. Women of childbearing potential should use effective contraception during treatment.
  • Lactation: Not recommended for breastfeeding due to a lack of human data, although animal studies have not shown direct or indirect harmful effects.
✔️ Precautions & Warnings
  • Renal Excretion: Prucalopride is mainly eliminated through renal excretion.
    • Recommended Dose for Severe Renal Impairment: 1 mg once daily.
  • Hepatic Impairment: Caution is advised in patients with severe hepatic impairment (Child-Pugh class C). Start with 1 mg once daily, which may be increased to 2 mg if well tolerated.
  • Diarrhea: Severe diarrhea may reduce the efficacy of oral contraceptives. An additional contraceptive method is recommended to prevent failure of oral contraception.
  • Lactose Content: Contains lactose; unsuitable for patients with hereditary galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.
✔️ Overdose Effects of Prulax 1
  •  Symptoms: Overdose may lead to symptoms such as:
    • Exaggeration of known effects (headache, nausea, diarrhea).

Management:

  • Specific treatment for overdose is not available. Management should be symptomatic and supportive. Correct any electrolyte disturbances due to fluid loss from diarrhea or vomiting.

Adverse reactions are more common at the start of therapy and typically resolve within a few days. Most events are mild to moderate in intensity.

✔️
  • Store at room temperature, below 30°C.
Frequently Asked Questions (FAQ)

No

Prulax 1 can be taken at any time of the day. Normally, it is taken orally with or without food once daily. The exact dosage of this medication is to be decided by your prescribing physician. Usually, it is taken as 2 milligrams per day.

Take Prulax 1 as advised by your physician. It can be taken with or without food, at any time of the day. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the condition.
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Check our pricing section for Prulax 1 price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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