Prucalopride is prescribed for the treatment of chronic idiopathic constipation in adults. This condition is characterized by:
Not recommended for individuals under 18 due to insufficient safety and effectiveness data.
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Prulax 1 contains Prucalopride, a gastrointestinal prokinetic agent used to treat chronic constipation in adults where conventional treatments (like laxatives) have been ineffective. Constipation is characterized by infrequent, hard, or painful bowel movements.
Prucalopride works by activating specific receptors in the intestinal walls (5-HT4 receptors). This stimulates contractions in the walls of the intestine, increasing the frequency of bowel movements and relieving constipation.
Prulax 1 is contraindicated in:
- Patients undergoing renal dialysis.
- Those with perforation or obstruction of the gut wall.
- Patients with severe inflammation of the intestinal tract, such as Crohn’s disease, ulcerative colitis, or toxic megacolon/megarectum.
- Patients who have recently undergone bowel surgery.
Use Prulax 1 with caution in patients with:
Pregnancy: Not recommended for use. Breastfeeding: Not recommended due to lack of sufficient safety data.
Prulax 1 is not recommended for use in children or adolescents under 18 years of age.
It is not known if alcohol interacts with Prulax 1. Please consult your doctor if you have any concerns regarding this.
Avoid using Prulax 1 if you are pregnant or breastfeeding.
Not recommended due to lack of sufficient safety data.
Prulax 1 may cause dizziness and tiredness. Drive only if you feel alert.
Prulax 1 is not recommended for use in patients on renal dialysis. It should be used with caution in patients suffering from severe kidney diseases. Consult your doctor for advice before taking it.
Prulax 1 should be used with caution in patients with severe liver diseases. Consult your doctor before taking it.
It acts on the muscle walls of the gut to increase bowel motility, helping to restore normal bowel function and alleviate constipation.
You may experience:
Most side effects are mild and resolve over time. However, consult your doctor if any side effects persist or worsen.
Prucalopride is used in the treatment of constipation. It helps in relieving constipation that is long-lasting or keeps coming back.
Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be found throughout the gastrointestinal tract primarily in smooth muscle cells, enterochromaffin cells, and myenteric plexus. Its activation produces the release of acetylcholine which is the major excitatory neurotransmitter in the GI tract. Hence, prucalopride stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract which causes a release of acetylcholine and further contraction of the muscle layer of the colon and relaxation of the circular muscle layer leading to the propulsion of luminal content.
Keep your doctor informed about your health status and any medications you are taking to avoid potential interactions or unpleasant side effects.
Management:
Adverse reactions are more common at the start of therapy and typically resolve within a few days. Most events are mild to moderate in intensity.
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